研究方向

蛋白质-RNA复合物在转录和表观遗传层面如何调控基因表达，以及如何在细胞分化和癌症发生等命运决定过程中发挥作用。主要研究内容包括：

1、  RNA结合蛋白的转录调控机制；

2、  反向RNA的功能与作用机制研究；

3、  RNA-Protein研究的新技术开发。

 

学术成就

2010年于武汉大学获博士学位，2010年至2015在美国加州大学圣地亚哥分校进行博士后研究工作。主要从事RNA结合蛋白和非编码RNA在细胞重编程、干细胞分化及癌症发生过程中的功能机制研究。近年来主要围绕RNA结合蛋白和microRNA (miRNA)在神经细胞重编程、癌症发生和干细胞分化等方面的作用开展了系统性探索, 取得了前沿性突破,在Cell, Mol Cell, Nature, Gen Dev, Cell Research等发表10多篇科研论文。

 

代表论文

1. Zhaokui Cai, Changchang Cao, Lei Ji, Rong Ye, Di Wang, Cong Xia, Sui Wang,Zongchang Du, Naijing Hu, Xiaohua Yu, Juan Chen, Lei Wang, Xianguang Yang,Shunmin He & Yuanchao Xue(*). RIC-seq for global in situ profiling of RNA–RNA spatial interactions. Nature  (2020)

2. Juan Chen, Zhaokui Cai, Meizhu Bai, Xiaohua Yu, Chao Zhang, Changchang Cao, Xihao Hu, Lei Wang, Ruibao Su, Di Wang, Lei Wang, Yingpeng Yao, Rong Ye, Baidong Hou, Yang Yu, Shuyang Yu, Jinsong Li, Yuanchao Xue(*). The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes.Cell Research, 2018, 28: 981-995 (Cover story).

3.Yuanchao Xue(#)，Kunfu Ouyang，Jie Huang，Yu Zhou，Hong Ouyang，Hairi Li，Gang Wang，Qijia Wu，Chaoliang Wei，Yanzhen Bi，Li Jiang，Zhiqiang Cai，Hui Sun，Kang Zhang，Yi Zhang，Ju Chen，Xiang-Dong Fu(*)，Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits，Cell, 2013, 152 (1–2): 82-96

4. Yuanchao Xue(#)(*) ，Hao Qian(#) ，Jing Hu，Bing Zhou，Yu Zhou，Xihao Hu，Aziz Karakhanyan，Zhiping Pang，Xiang-Dong Fu(*)，Sequential Regulatory Loops as Key Gatekeepers for Neuronal Reprogramming in Human Cells，Nature Neuroscience 2016 Jun;19(6):807-15. doi: 10.1038/nn.4297.

5. Schaffer AE, Eggens VR, Caglayan AO, Reuter MS, Scott E, Coufal NG, Silhavy JL, Xue Y, Kayserili H, Yasuno K, Rosti RO, Abdellatef M, Caglar C, Kasher PR, Cazemier J, Weterman M, Cantagrel V, Cai N, Zweier C, Altunoglu U, Satkin NB, Bilguvar K, Tuysuz B, Yalcinkaya C, Caksen H, Aktar F, Fu XD, Gabriel S, Reis A, Gunel M,Baas F, Gleeson JG. CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration. Cell  2014, April 24, 157, 1–13

6. Ouyang, Hong(#)，Xue, Yuanchao，Lin, Ying，Zhang, Xiaohui，Xi, Lei，Patel, Sherrina，Cai, Huimin，Luo, Jing，Zhang, Meixia，Zhang, Ming，Yang, Yang，Li, Gen，Li, Hairi，Jiang, Wei，Yeh, Emily，Lin,Jonathan，Pei, Michelle，Zhu, Jin，Cao, Guiqun，Zhang, Liangfang，Yu, Benjamin，Chen, Shaochen，Fu, Xiang-Dong(*)，Liu, Yizhi(*)，Zhang, Kang(*)，WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis， Nature, 2014, 511(7509)：358-361

7. Yuanchao Xue(#), Yu Zhou(#), Tongbin Wu, Tuo Zhu, Xiong Ji, Young-SooKwon, Chao Zhang, Gene Yeo, Douglas L. Black, Hui Sun, Xiang-Dong Fu(*), Yi Zhang(*), Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping，Molecular Cell，2009，36（6）：996-1006